Treatment #5 – I3C/DIM (Natural SERMS) and Supplements
May 15, 2010
In view of the diagnosis that Nanay metabolizes her estrogen towards the bad metabolite 16OH. The doctor said, the idea is not to remove estrogen at all (as we still need estrogen for some other bodily functions), but to support the liver/kidneys so that estrogen is metabolized towards the better metabolite (2OH) rather than 16OH.
Lowering levels of 16OH can be achieved via indole-3-carbinoal (I3C) or diindolmetahne (DIM), which are phtyochemicals (natural chemicals) from cruciferous vegetables such as brocolli, cauliflower, cabbage, kale etcetera.
So, she was given 2 month’s worth of capsules contatining the following:
Brocolli plant and sprout concentrated extract – 400mg
I3C – 80mg
Rosemary Extract – 50mg
Cat’s Claw Bark extract – 50mg
Trans-resveratrol (from grapes)- 20 mg
Cabbage extract – 25mg
Although 16OH is known as a carcinogenic, it also important in maintaining bone mineral density. So, if we lower 16OH levels, we will have less protection for our bones.
In view of that, Nanay was also given 2 months worth of capsules containing the following:
Calcium D-Glucarate (200mg) and
I3C/DIM enhances the metabolism and excretion of estrogen. The reason why there are added herbs/supplemnents such as Cat’s Claw is to support the liver & kidney during the elimination process of the bad estrogen metabolites.
Tamoxifen on the other hand acts as an anti-estrogen which blocks estrogen receptor sites. Nanay asked Doctor Lee if she should continue using Tamoxifen. The good doctor said he is not a fan of Tamoxifen, however, he cannot ask a patient to get off Tamoxifen, either the patient makes a decision for herself or the patient can ask her oncologist about it. Nanay decided not to continue Tamoxifen.