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Enzymes (macrophages) eating tumuor cells

May 6, 2011

An uncompromised immune system have an ability to activate specific enzymes (macrophages) that eats abnormal cells. However, cancer cells seems to have a mind of its own, and secretes another type of enzyme that prevents the activitation of good enzymes (macrophages), so that it cannot eat the cancer cells. Oh yeah there are good (macrophages) and bad (Nagalese) enzymes in the same way there are good/bad estrogen, good/bad bacteria and good/bad cholesterol.
The clinical study here:

“Serum vitamin D3-binding protein (Gc protein) is the precursor for the principal macrophage activating factor (MAF). The MAF precursor activity of serum Gc protein of breast cancer patients was lost or reduced because Gc protein was deglycosylated by serum alpha-N-acetylgalactosaminidase (Nagalase) secreted from cancerous cells. Patient serum Nagalase activity is proportional to tumor burden. ”

Nagalase is an enzyme secreted by cancerous cells (the N cutter in the video), During the clinical testing scientists have a way of measuring the level of Nagalase enzymes in the blood plasma. However, as of current time this is not a standard test, Nagalase testing is only being done withing the clinical trials and a lab in Netherlands.

The deglycosylated Gc protein cannot be converted to MAF, resulting in no macrophage activation and immunosuppression.

” What is the importance of knowing the levels of Nagalase in your blood plasma? Once
theNagalase enzyme cuts off the “N” then the macrophage does not bind into the GcF, and does not activate and does not eat the tumour cells/cancer cells at all.”

So how can we trick the cancer cells– so that the macrophages are activated?
Stepwise incubation of purified Gc protein with immobilized beta-galactosidase and sialidase generated probably the most potent macrophage activating factor (termed GcMAF) ever discovered, which produces no adverse effect in humans.
Dr. Yamamoto and his colleagues were able to incubate the Gc protein so that it can activate the macrophages in the body. They call this GC-MAF (Gc- Macrophage activating factor). The cure is to extract Gc Protein from blood; modify it outside the body to become the missing Gc-MAF, and inject it once a week for several weeks. Since macrophages are part of the immune system– its very natural, and was proven that there are no adverse side effects in humans. Note: I have some reason to believe that Dr. Yamamoto have built up on what Dr. Kelley and Dr. Gonzalez had started a few decades ago.They were ridiculed because of their theories about cancer being coated with some type of protein. It is a well know fact that there are different types of protein (plant protein requires plant enzymes , animal proteins require animal enzymes).

Macrophages treated in vitro with GcMAF (100 pg/ml) are highly tumoricidal to mammary adenocarcinomas. Efficacy of GcMAF for treatment of metastatic breast cancer was investigated with 16 nonanemic patients who received weekly administration of GcMAF (100 ng).

GcMAF was tested on 16 nonanemic breast cancer patients with metastatic– who were given 100ng of GcMAF weekly .. this a trial on human not rats!

As GcMAF therapy progresses, the MAF precursor activity of patient Gc protein increased with a concomitant decrease in serum Nagalase.
during the treatment, they measured the Nagalese levels in the patients’ blood plasma and found out that there is a corresponding decrease in serum Nagalese

Because of proportionality of serum Nagalase activity to tumor burden, the time course progress of GcMAF therapy was assessed by serum Nagalase activity as a prognostic index.

because of the corresponding decrease in the levels of Nagalase in the blood plasma, the scientists decided that they can assess the success of the treatment by measuring Nagalase in the blood.. the lower the Nagalase.. the better it is

These patients had the initial Nagalase activities ranging from 2.32 to 6.28 nmole/min/mg protein. After about 16-22 administrations (approximately 3.5-5 months) of GcMAF, these patients had insignificantly low serum enzyme levels equivalent to healthy control enzyme levels, ranging from 0.38 to 0.63 nmole/min/mg protein, indicating eradication of the tumors. This therapeutic procedure resulted in no recurrence for more than 4 years.
Healthy people– that is people with no cancer have Nagalase enzyme levels from 0.38 to 0.3 nmole/min/mg protein. Those who have breast cancer have Nagalase enzyme levels ranging from 2.32 to 6.28 nmole/min/mg protein…. the goal is to reduce it to this range (0.38 to 0.63). The question is where can we get ourselves tested on Nagalase enzyme levels (in the blood)… The Bio Group Labs offer Nagalese testing, but only in Netherlands: and where can we get the same GcMAF used by Dr. Yamamoto and his team during the clinical trials? When would clinical trials be conducted in Singapore?? In Europe, several doctors conducted the trials themselves. There are also online sites selling GcMAF, but I would rather purchase GcMAF from someone I can see physically and who can also order the Nagalese testing. I do understand however, that there are no labs in Singapore that is capable of or at least know that there is such a thing as Nagalese testing. Going to Netherlands to see the doctors ordering the test and offering GcMAF injections — seems to be a very expensive but quite an exciting plan… hmmmm! I wonder how much it would cost me to stay in Netherlands for 3 months including air fare back and forth?? One thing I am quite sure of the cure for cancer still depends on how strong our immune system is— that is if our immune system recognizes cancer as the enemy–the problem is the cancer cells find a way to escape the radar of our immune systems (in the same way Osama bin laden has escaped the authorities for a long time). Just thinking out loud. I am still on a wait and see mode as far as GcMAF is concerned. The science behind it makes sense, but still I doubt the organizations offering it. Dr. Yamamot is now more than 80 years old (took 15 years of his life to discover GcMAF- but I guess he does not have the passion to make it to market). It makes me all the more concerned about those people who are taking chemo and making their immunities all the more compromised.

12 Comments leave one →
  1. May 12, 2011 6:35 pm

    Dear people, BGLI can help you get Nagalase and VDR genotyping testing and GcMAF. Travelling to Holland is not necessary.

  2. May 12, 2011 11:44 pm

    BGLI, you sound like David Noakes too… I am sorry, its just that sometimes, its too good to be true. I do hope I would have enough money to go to places where clinics actually offer it..

  3. May 13, 2011 3:24 pm

    Dear Nanay, please do not say that. We work with physicians only. Have your physician contact us. I was only trying to say that you do not have to travel so far. We work with physicians around the world.

  4. May 13, 2011 6:34 pm

    you mean oncologists would also consider this? Please understand that we are already getting “scolded” by our oncologists for saying no to conventional treatments. I wonder how they would react to something like this.

  5. May 13, 2011 6:39 pm

    Hi Nanay, just contact bgli and they will guide you through all this. Promise. There’s a contact email form, paste in the link to this thread along with your information.

  6. May 16, 2011 9:26 pm

    link to the patent for testing Nagalase activities

    for some reason, I cannot find the patent pending for GC-MAF

  7. May 18, 2011 6:36 pm

    an analysis on GC-MAF and other sources of N-acetylgalactosamine

    What Dr. Yamamoto refers to as “MAF” is a molecule primarily (if not completely) composed of N-acetylgalactosamine which happens to be one of the 8 most ESSENTIAL monosaccharides aka glycoproteins (aka glyconutrients) for proper cellular communication. They act as “antennas” on the cell membranes.

  8. May 18, 2011 8:05 pm

    Difference between protease inhibitors and proteas enzyme therapy

  9. Janis permalink
    October 11, 2012 1:19 pm

    There is a doctor in Reno NV that has access to the GcMAF injections. I started them about 6 weeeks ago and my Nagalase test is down to 1.1, Check out the Reno Integrative Medical Center. Its a great place


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